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KMID : 0378019950380030020
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New Medical Journal
1995 Volume.38 No. 3 p.20 ~ p.30
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Ten-year Follow-up on the Changes of Hepatitis B Virus Markers and Liver Function among Employees of a Hospital
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Abstract
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This study was carried out to identify the prevalence and the chronological changes of serological markers of hepatitis B virus infection and liver functions among employees of a hospital. Three hundred and forty-seven (347) persons were examined initially in May 1984, and 137 persons were reexamined in June 1994. They were interviewed according to the structured questionnaire, examined by physician, and blood was drawn for the tests. RPHA and PHA method in 1984 and ELISA method in 1994 were used to determine HBsAg and anti-HBs. UV method was used to determine SGOT and SGPT.
The results are as follows.
1. The prevalence rate of HBsAg positive in 1984 was 9.2% and anti-HBs positive was 9.5% among 347 persons. The liver functions were belonged to normal ranges.
2. HBsAg positive rate by sex showed higher in females(10.9%) than males(7.4%). HBsAg positive rate revealed the highest on 30-39 years age group (13.3%) and clerical workers(13.0 %). But these differences were not statistically significant. Anti-HBs positive rate by sex showed higher in females (9.8%) than males (9.2%). anti-HBs positive rate revealed the highest on the age group older than 40 years (12.0%) and physicians (16.2%). But these differences were not statistically significant.
3. Age-adjusted HBsAg positive rate in 1994 was 9.5% and decreased slightly than 10.4% in 1984
among 137 persons, although statistically not significant. Whereas age-adjusted anti-HBs
positive rate in 1994 was 721 % and remarkably increased than 8.4% in 1984 (p<0.01).
4. HBsAg positive rate in 1994 was 78.6% and HBsAg loss rate was 21.4% among 14 persons of
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